According to many researches, the onset of migraine may occur due to mitochondrial dysfunction. CoQ10, an essential element in the mitochondrial electron transport chain (used to make usable energy in the cell), may be an effective agent in preventing migraines.
In a clinical trial conducted at the Cleveland Clinic Foundation, 31 patients showed a significant reduction in the average number of days with migraine after 3 months of treatment. Migraine frequency fell from 4.85 attacks at the start to 2.81 at the study conclusion. The administered dose was 150 mg daily. No side effects were observed (Rosen 2002).
Overall, studies indicate that CoQ10 can cut the frequency of migraines in half in about 61% of people at a dose of 150 mg per day for 3 months. CoQ10 has been shown to be well tolerated at doses less than 300 mg per day; higher doses may cause nausea and diarrhea in some people.
CoQ10 has shown to be especially useful for those people in which the usual migraine medications don’t work, providing a valuable therapy for those that feel they don’t have many options.